Diagnostic Pitfalls in Aspiration Biopsy Cytology of Papillary Breast Lesions.

نویسندگان

  • Ku
  • Mela
  • Cox
  • Reintgen
  • Nicosia
چکیده

Our experience with 12 papillary breast lesions included eight intraductal papillomas, three primary papillary carcinomas, and one metastatic papillary ovarian carcinoma. Five of the eight intraductal papillomas displayed diagnostic findings including tridimensional papillary fragments of ductal cells with distended cytoplasmic vacoules and dense scalloped cytoplasm. Three intraductal papillomas displayed cohesive fragments containing epithelial cells surrounding metachromatic, globoid, and cylindrical structures that were bright red following Diff-Quik staining and pale blue following Papanicolaou staining. Such unusual findings may raise the differential diagnoses of adenoid cystic carcinoma and collagenous spherulosis. However, the metachromatic material of intraductal papilloma represents type-I collagen-rich stroma of hyalinized fibrovascular stalks, while the material of adenoid cystic carcinoma and collagenous spherulosis represents type-IV collagen. Two of the three primary papillary carcinomas displayed cytologic findings similar to those of intraductal papillomas except for increased anisonucleosis and cell dyshesion, while the third displayed innumerable psammoma bodies similar to the metastatic ovarian carcinoma.

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عنوان ژورنال:
  • Cancer control : journal of the Moffitt Cancer Center

دوره 4 5  شماره 

صفحات  -

تاریخ انتشار 1997